Orthobiologics involves the use of naturally occurring biologic substances, like scaffolds, cells or proteins, that your health care provider may use to help heal injuries to bone, cartilage, tendons or ligaments. Orthobiologic products may be derived from several sources. If the product comes directly from the patient, it is an autograft. If the product comes from donated human tissue, it is an allograft. In some cases, biologic materials may also be a combination of synthetic and biologic materials.